1H-INDAZOLE, 4-IODO-1-METHYL-

1H-INDAZOLE, 4-IODO-1-METHYL- - Names and Identifiers

Name	4-iodo-1-methyl-1H-indazole
Synonyms	1-Methyl-4-iodoindazole 4-iodo-1-methylindazole 4-iodo-1-methyl-1H-indazole 4-Iodo-1-methyl-1H-indazole 1H-INDAZOLE, 4-IODO-1-METHYL-
CAS	935661-15-7
InChI	InChI=1/C8H7IN2/c1-11-8-4-2-3-7(9)6(8)5-10-11/h2-5H,1H3

1H-INDAZOLE, 4-IODO-1-METHYL- - Physico-chemical Properties

Molecular Formula	C8H7IN2
Molar Mass	258.06
Storage Condition	2-8°C
Refractive Index	1.718

1H-INDAZOLE, 4-IODO-1-METHYL- - Introduction

4-iodo-1-methyl-1H-indazole is an organic compound with the molecular formula C9H8IN and a molecular weight of 261.08g/mol. The following is its nature, use, preparation and safety information:

Nature:
-Appearance: 4-iodo-1-methyl-1H-indazole is a white crystalline solid.
-Melting point: about 132-135°C.
-Solubility: Soluble in organic solvents such as methanol and dichloromethane, insoluble in water.

Use:
-Chemical reagents: 4-iodo-1-methyll-1H-indazole is often used as an intermediate for the synthesis of other organic compounds.
-Drug research: It is also used in drug research, especially in the synthesis of new drugs and the study of biological activity.

Method:
The preparation method of 4-iodo-1-methyll-1H-indazole is more complicated, and one of the synthesis methods is as follows:
1. First, 4-bromo-1-methylindazole is reacted with acetic acid and sodium iodide to generate the intermediate of 4-iodo-1-methyl-1H-indazole.
2. The bromine atom in the intermediate is then replaced with an iodine atom by a reaction using a chloromethylating agent such as methyl chloride and an alkaline solution.
3. Finally, the product is purified by heat treatment and crystallization.

Safety Information:
- 4-iodo-1-methyl-1H-indazole should be careful to avoid contact with skin, eyes and mucous membranes during use. Wear protective gloves, goggles and respiratory protection.
-When storing, it should be placed in a cool, dry, well-ventilated place, away from heat and flammable materials.
-Do not mix this compound with strong oxidants or strong acids to avoid dangerous reactions.
-In the event of contact or ingestion, seek medical help immediately and show their chemical label or provide information to your doctor.

Last Update：2024-04-09 15:18:00